The quarterback failed to reach his usual high standards as the Chiefs were beaten 40-22 by the Philadelphia Eagles in Sunday's (09.02.25) NFL showpiece and confessed that the disappointment of defeat will stay with him for the rest of his career.
Mahomes said: "There's no way around it. Anytime you lose a Super Bowl, it's the worst thing in the world... it will stick with you the rest of your career.
"I mean these will be the two losses that will motivate me to be even better, for the rest of my career. Because you only get so few of these [Super Bowls], and you have to capitalise on them.
"It's going to hurt for a while, but how can you respond from it?"
Mahomes' throwing was off during the Super Bowl but he also praised the Eagles' defence for their efforts as they ruined the Chiefs' ambitions to become the first franchise to win three Vince Lombardi Trophies in a row.
The star said: "They played great from start to finish. They got after it.
"We didn't start how we wanted to. The turnovers hurt... I take all the blame for that. Those turnovers swing the moment of the game and they capitalised on them.
"They scored on one and got a touchdown immediately after another. That's 14 points I gave them.
"It's hard to come back from that in the Super Bowl. I have to learn from that and try to be better the next opportunity that I hopefully get.
"I didn't play to my standard and I have to be better next time."