The technology titan is pulling the plug on the note-taking app on October 14, 2025 - the same day as Microsoft withdraws support for the operating system, which initially debuted in July 2015.
Announcing the news in the Microsoft 365 Message Centre, the firm said: "As we continue to enhance OneNote with a unified and modern experience, we want to remind you that OneNote for Windows 10 will reach end of support on October 14, 2025.
"To avoid disruptions, we strongly urge your organisation to fully transition to OneNote on Windows (OneNote M365) and uninstall the legacy application as soon as possible.
"Migrating ensures continued access to the latest features, security updates, and a modernised experience."
After the deadline, OneNote for Windows 10 will not receive any updates, and it will not be searchable nor available to be installed in the Microsoft app store.
However, a free version of the app can still be accessed online on Microsoft 365.
In January, Microsoft - which was co-founded in 1975 by Bill Gates and Paul Allen - announced it is ending Windows 10 Office apps support on October 14
Its suite of apps, such as Word, PowerPoint and Excel, on the operating software, will also not be given new updates, but it "will continue to function as before".
However, over time, there could be "performance and reliability issues".
Microsoft's support withdrawal for Windows 10 will see security and feature updates cease for older machines.
Due to the new operating system having much bigger hardware requirements, Microsoft's older systems cannot meet the requirements.
Writing in a blog post earlier this month, Yusef Mehdi, chief marketing officer at Microsoft, hailed 2025 as "the year of the Windows 11 PC refresh".
He added: "Whether the current PC needs a refresh, or it has security vulnerabilities that require the latest hardware-backed protection, now is the time to move forward with a new Windows 11 PC."