The direct route will see aircraft travel from Belfast International Airport to Punta Cana International Airport on the Caribbean island.
The routes will run for four weeks from June 20, 2026, and will operate a weekly service.
Outbound flights will depart from Belfast International Airport at 11:20 am, before landing in Punta Cana at 2:40 pm.
The flight duration is around eight hours and 20 minutes - far quicker than journeys to Barbados or Jamaica.
Prices start from £878 per person, when travelling for 14 days.
The low prices in the Dominican Republic are a major lure for tourists whilst the island also contains sandy beaches and fantastic resorts.
Craig Morgan, Head of Ireland for TUI, said: "We are delighted to offer our customers in Northern Ireland the opportunity to experience the Dominican Republic with our new direct flights from Belfast next summer.
"This is the only direct flight available from Belfast to Dominican Republic and it will open up an exciting range of hotels and unique holiday experiences for Northern Ireland's holidaymakers to enjoy in the breathtaking Dominican Republic."
Dan Owens, CEO of Belfast International Airport, added: "The Dominican Republic is a must-see destination for any traveller, and we are thrilled that TUI is introducing this new direct route to Punta Cana International Airport.
"This route is a welcome addition to the TUI network and part of our commitment to develop direct routes for travellers direct from their local airport."
